


The fastest route from the start of the game (Prisoner’s Cells) is to travel to the Toxic Crypt using the Vine Rune and head down to the Old Sewers.
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If you’re not sure how to get there, you can reach it through the Insufferable Crypt, but be warned, you will have to face the Watcher boss along the way. The Spider Rune can always be found in the Slumbering Sanctuary. The Spider Rune is one of the last Runes you’re likely to gain access to, and you’ll need to use the other Runes to reach it, so make sure you’ve grabbed them first.

Once obtained it’s yours for good, and you check which Runes you’ve collected so far on the right-hand side of the pause screen. To gain the Rune you’ll need to beat certain Elites spawned from Elite Obelisks. Regardless of the level arrangement, each Rune can always be found in a specific area, guarded by powerful Elite enemies.
